Okui T, Endoh D, Arai S, Hayashi M
Hokkaido Institute of Public Health, Sapporo, Japan.
J Vet Med Sci. 1996 Aug;58(8):795-7. doi: 10.1292/jvms.58.795.
The LEC strain of rats (LEC rats), originally developed as a model for hereditary fulminant hepatitis, is highly sensitive to whole-body X-irradiation when compared to WKAH strain of rats (WKAH rats). The present results showed that frequencies of certain types of chromosome aberrations induced by in vitro X-irradiation in the fibroblasts of LEC rats were higher than those of WKAH rats. In particular, frequencies of chromatid gaps and chromosome exchanges in LEC cells were higher approximately 4- to 5-fold and 6- to 8-fold, respectively, than those of WKAH cells.
LEC大鼠品系最初作为遗传性暴发性肝炎的模型培育而成，与WKAH大鼠品系相比，对全身X射线照射高度敏感。目前的结果表明，体外X射线照射诱导的LEC大鼠成纤维细胞中某些类型染色体畸变的频率高于WKAH大鼠。特别是，LEC细胞中染色单体间隙和染色体交换的频率分别比WKAH细胞高约4至5倍和6至8倍。
