Hayashi M, Endoh D, Kon Y, Yamashita T, Sato F, Kasai N, Namioka S
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
J Vet Med Sci. 1993 Feb;55(1):13-8. doi: 10.1292/jvms.55.13.
LEC strain rats, which have been known to develop hereditarily spontaneous fulminant hepatitis 4 to 5 months after birth, were highly sensitive to whole-body X ray-irradiation as compared to WKAH strain rats. Radiation-induced acute bone-marrow death occurred at doses higher than 2.0 Gy in LEC rats, and at doses higher than 7.4 Gy in WKAH rats, respectively. By probit analysis of survival data, it was shown that the LD50/30 value for LEC rats was 3.0 Gy which was significantly lower than that (7.8 Gy) of WKAH rats. Histopathological examinations of the bone marrows from both strains after irradiation at a dose of 4.0 Gy revealed that a number of hemopoietic cells were recovered in WKAH rats on day 8 after irradiation, but not in LEC rats. These results suggested the hypersensitivity of LEC rats to ionizing radiation in connection with acute bone-marrow death.
已知LEC品系大鼠在出生后4至5个月会发生遗传性自发性暴发性肝炎，与WKAH品系大鼠相比，它们对全身X射线照射高度敏感。辐射诱导的急性骨髓死亡分别发生在LEC大鼠高于2.0 Gy的剂量和WKAH大鼠高于7.4 Gy的剂量下。通过对生存数据的概率分析表明，LEC大鼠的LD50/30值为3.0 Gy，显著低于WKAH大鼠的（7.8 Gy）。对两种品系大鼠在4.0 Gy剂量照射后的骨髓进行组织病理学检查发现，照射后第8天WKAH大鼠中有许多造血细胞恢复，但LEC大鼠中没有。这些结果表明LEC大鼠对与急性骨髓死亡相关的电离辐射高度敏感。
