慢性丙型肝炎感染中病毒血症的动态研究。

A dynamic study of viraemia in chronic hepatitis C infection.

作者信息

Meng Z D, Sun Y D, Sun D G, Liu C Y, Copland J, Gowans E J

机构信息

Hygiene and Anti-epidemic Station of Hebei Province, China.

出版信息

J Gastroenterol Hepatol. 1994 May-Jun;9(3):242-4. doi: 10.1111/j.1440-1746.1994.tb01717.x.

DOI:10.1111/j.1440-1746.1994.tb01717.x

PMID:7519895

Abstract

The dynamics of alanine aminotransferase (ALT), anti-hepatitis C virus and hepatitis C virus (HCV) RNA in six cases with chronic HCV infection were studied for 3-7 years. Two of the six cases showed continued elevation of ALT, and three showed intermittent elevation. All cases were persistently positive for anti-HCV after initial seroconversion. Five of the six cases were persistently positive for HCV RNA detected by nested polymerase chain reaction, and one was positive intermittently. Thus hepatitis C virus replicates continually in a majority of patients with chronic hepatitis C, although some cases may show intermittent replication, and replication of hepatitis C virus does not always correlate with elevated ALT.

摘要

对6例慢性丙型肝炎病毒（HCV）感染患者的丙氨酸氨基转移酶（ALT）、抗丙型肝炎病毒及丙型肝炎病毒（HCV）RNA动态变化进行了3至7年的研究。6例患者中有2例ALT持续升高，3例呈间歇性升高。所有病例在初次血清学转换后抗HCV均持续阳性。6例患者中有5例通过巢式聚合酶链反应检测HCV RNA持续阳性，1例呈间歇性阳性。因此，尽管部分病例可能表现为间歇性复制，但在大多数慢性丙型肝炎患者中丙型肝炎病毒持续复制，且丙型肝炎病毒复制并不总是与ALT升高相关。