Robertson J D, Bonaventura J, Kohm A P
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
Proc Biol Sci. 1994 Jun 22;256(1347):269-73. doi: 10.1098/rspb.1994.0080.
Nitric oxide, produced by nitric oxide synthase in brain tissue, is essential for several different kinds of learning in vertebrates. We present the first evidence that it is also essential for learning in an invertebrate. Intramuscular injections of an inhibitor of the enzyme completely block touch learning in Octopus vulgaris. Eight control animals learned a touch paradigm, but none of eight synthase-inhibited ones learned it.
一氧化氮由脑组织中的一氧化氮合酶产生，对脊椎动物的几种不同类型的学习至关重要。我们首次证明，它对无脊椎动物的学习也至关重要。向普通章鱼肌肉内注射该酶的抑制剂会完全阻断其触觉学习。八只对照动物学会了一种触觉模式，但八只注射了合酶抑制剂的动物都没有学会。
