Garber G E
Division of Infectious Diseases, Ottawa General Hospital, University of Ottawa, Ontario, Canada.
Drugs. 1994 May;47(5):734-40. doi: 10.2165/00003495-199447050-00003.
Infections due to Candida spp. are increasing in incidence as the number of immune compromised patients increases. The common presentation of Candida mucositis and oral infections includes atrophic candidiasis, angular cheilitis, leukoplakia and oesophagitis. An increasing spectrum of antifungal agents, including imidazoles, are available for treatment and suppression of this common infection. In chronically immune-compromised patients such as those with severe HIV related immune deficiency, eradication of the infection may not be possible. This requires a stepwise approach to management and may require the use of potent, toxic agents such as amphotericin B to suppress the symptoms and signs of infection sufficiently to provide the patient with symptomatic relief. Resistant organisms are also becoming a greater problem in this patient population.
随着免疫功能低下患者数量的增加，念珠菌属感染的发病率也在上升。念珠菌性粘膜炎和口腔感染的常见表现包括萎缩性念珠菌病、口角炎、白斑病和食管炎。越来越多的抗真菌药物，包括咪唑类药物，可用于治疗和抑制这种常见感染。在慢性免疫功能低下的患者中，如患有严重HIV相关免疫缺陷的患者，可能无法根除感染。这需要采取逐步的管理方法，可能需要使用强效、有毒的药物，如两性霉素B，以充分抑制感染的症状和体征，为患者提供症状缓解。耐药菌在这一患者群体中也日益成为一个更大的问题。
