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Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771.

作者信息

Chen T S, Arison B H, Wicker L S, Inamine E S, Monaghan R L

机构信息

Merck Sharp & Dohme Research Laboratory, Rahway, New Jersey 07065.

出版信息

J Antibiot (Tokyo). 1992 Jan;45(1):118-23. doi: 10.7164/antibiotics.45.118.

DOI:10.7164/antibiotics.45.118
PMID:1372307
Abstract

The immunosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.

摘要

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