Chen T S, Arison B H, Wicker L S, Inamine E S, Monaghan R L
Merck Sharp & Dohme Research Laboratory, Rahway, New Jersey 07065.
J Antibiot (Tokyo). 1992 Jan;45(1):118-23. doi: 10.7164/antibiotics.45.118.
The immunosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.