亚硫酰二氯酚及其代谢产物在沙门氏菌/哺乳动物微粒体试验中的致突变性。

Mutagenicity of bithionol sulfoxide and its metabolites in the salmonella/mammalian microsome test.

作者信息

Mourot D, Mourot A

出版信息

Mutat Res. 1987 May;188(1):53-5. doi: 10.1016/0165-1218(87)90114-5.

Abstract

The mutagenic effects of bithionol sulfoxide and its two major metabolites, bithionol and bithionol sulfone, on 4 Salmonella typhimurium strains (TA97, TA98, TA100 and TA102) were investigated. Bithionol sulfoxide was found to be mutagenic to TA98 and TA100. However, mutagenicity was abolished in the presence of rat-liver S9 fractions.

摘要

研究了亚砜基双硫酚及其两种主要代谢产物双硫酚和双硫醚砜对4种鼠伤寒沙门氏菌菌株（TA97、TA98、TA100和TA102）的诱变作用。发现亚砜基双硫酚对TA98和TA100具有诱变作用。然而，在存在大鼠肝脏S9组分的情况下，诱变活性消失。