Parekh R B, Edge C J
Oxford GlycoSystems, Blacklands Way, Abingdon, UK.
Trends Biotechnol. 1994 Sep;12(9):339-45. doi: 10.1016/0167-7799(94)90034-5.
Inflammation can be a beneficial response in the host for the control of infection and injury. However, occasionally, the inflammatory response can result in acute systemic collapse or, more frequently, a chronic reaction such as that observed in autoimmune disease, Crohn's disease and asthma. Injury to tissues or organs results in leukocyte adhesion to the endothelial cell surface, followed by diapedesis. Investigation of the initial leukocyte-endothelium adhesion processes has clearly shown the involvement of an inducible set of molecules, called selectins, on the endothelial and leukocyte cell surfaces. These molecules are of interest as the interactions with their respective ligands appear to involve carbohydrates. The exact nature of these interactions is still being elucidated. Therapeutic intervention using carbohydrate small-molecule mimetics may be beneficial in the modification of the inflammatory process.
炎症在宿主体内可能是一种控制感染和损伤的有益反应。然而，炎症反应偶尔会导致急性全身性衰竭，或者更常见的是引发慢性反应，如在自身免疫性疾病、克罗恩病和哮喘中观察到的那样。组织或器官损伤会导致白细胞黏附于内皮细胞表面，随后发生白细胞渗出。对白细胞与内皮细胞初始黏附过程的研究清楚地表明，在内皮细胞和白细胞表面存在一组可诱导的分子，称为选择素。这些分子备受关注，因为它们与各自配体的相互作用似乎涉及碳水化合物。这些相互作用的确切性质仍在阐明之中。使用碳水化合物小分子模拟物进行治疗干预可能有助于改变炎症过程。
