Paramonova M S, Gagarinova V M, Rodina M A, Guseva V M, Burmistrova V V, Osipova Z A, Aksenov O A
Vopr Virusol. 1994 May-Jun;39(3):131-4.
The antiviral and interferon-inducing activity of saparal, an adaptogen of plant origin, was studied. Tests in experimental mice demonstrated the interferon-inducing activity of saparal providing its antiviral effect. An optimal scheme of saparal administration was developed. The preparation had no direct inhibitory effect on influenza virus replication. The application of saparal for prophylaxis among workers resulted in a 2-fold or greater decrease of influenza and other ARD morbidity and in an increase of endogenous serum interferon level in 67-75% of the persons examined.
对植物源适应原刺蒺藜皂甙的抗病毒和诱导干扰素活性进行了研究。在实验小鼠身上进行的试验证明了刺蒺藜皂甙的诱导干扰素活性，从而发挥其抗病毒作用。制定了刺蒺藜皂甙的最佳给药方案。该制剂对流感病毒复制没有直接抑制作用。在工作人员中应用刺蒺藜皂甙进行预防，可使流感和其他急性呼吸道疾病的发病率降低两倍或更多，并使67%至75%的受检者体内血清内源性干扰素水平升高。
