Kremerman I B, Priĭmiagi L S, Ershov F I
Vopr Virusol. 1984 Sep-Oct;29(5):549-53.
The results of screening of five national preparations for the interferon-inducing activity in white mice by various doses, schedules and routes of administration are presented. Their capacity to protect the animals against influenza, tick-borne encephalitis, and herpes viruses was evaluated. Cuthizon, zimosan, tiloron and its analogue IC-32 induced in mice endogenous interferon production in amounts from 40 to 640 IU50/ml. Tiloron, prodigiozin, and zimosan were found to be effective against influenza. Protective effect of zimosan in combination with polyguacyl was observed against tick-borne encephalitis.
本文展示了对五种国家制剂进行不同剂量、给药方案和给药途径的筛选，以评估其在小白鼠体内诱导干扰素活性的结果。同时评估了它们保护动物免受流感病毒、蜱传脑炎病毒和疱疹病毒侵害的能力。Cuthizon、酵母聚糖、泰洛龙及其类似物IC - 32可诱导小鼠产生40至640 IU50/ml的内源性干扰素。发现泰洛龙、灵菌红素和酵母聚糖对流感有效。观察到酵母聚糖与聚呱嗪联合使用对蜱传脑炎有保护作用。
