Matano S, Nakamura S, Ohtake S, Okumura H, Okabe Y, Kanno M, Takeshima M, Syouin K, Nonomura A, Yoshida T
Third Department of Internal Medicine, Kanazawa University, School of Medicine, Japan.
Acta Haematol. 1994;91(3):158-63. doi: 10.1159/000204323.
A 42-year-old man developed primary non-Hodgkin's lymphoma of the central nervous system (CNS). Immunohistochemical examination suggested that tumor cells were derived from T cells. Primary T cell non-Hodgkin's lymphoma of the CNS is a rare tumor, with only 12 well-documented cases in the literature. The clinical features of these 12 cases were similar to those of other CNS lymphomas, and the effect of treatment and prognosis were usually worse than those of extranodal lymphoma. Our patient, who was treated with partial tumor resection and whole-brain irradiation with a boost to the primary site and 5 courses of CHOP therapy (cyclophosphamide, doxorubicin, vincristine, prednisolone), is still alive and in remission 38 months after diagnosis.
一名42岁男性患原发性中枢神经系统非霍奇金淋巴瘤（CNS）。免疫组织化学检查提示肿瘤细胞来源于T细胞。原发性中枢神经系统T细胞非霍奇金淋巴瘤是一种罕见肿瘤，文献中仅有12例记录完整的病例。这12例病例的临床特征与其他中枢神经系统淋巴瘤相似，治疗效果和预后通常比结外淋巴瘤更差。我们的患者接受了肿瘤部分切除术、对原发部位进行加量的全脑照射以及5个疗程的CHOP治疗（环磷酰胺、阿霉素、长春新碱、泼尼松龙），诊断后38个月仍存活且处于缓解状态。
