Launay J M, Callebert J, Bondoux D, Loric S, Maroteaux L
FRA C. Bernard Neurochimie des Communications Cellulaires, Hôpital St. Louis, Paris, France.
Cell Mol Biol (Noisy-le-grand). 1994 May;40(3):327-36.
Since its discovery, serotonin (5-hydroxytryptamine = 5-HT) has become a major player on the neurotransmitter "stage". Multiple receptor subtypes for 5-HT have been identified and classified, and a vast pharmacology of 5-HT has emerged. In particular, 5-HT has been shown to exert marked effects on the cardiovascular system, central nervous system (CNS) and gastrointestinal (GI) tract, and important ligands have been developed that mimic or block its action selectively. Furthermore, drugs that release 5-HT, and others that prevent its uptake, have been developed. This brief review focuses on the pharmacology of 5-HT agonists and antagonists that exhibit, at least partly, clinical relevance.
自发现以来，血清素（5-羟色胺=5-HT）已成为神经递质“舞台”上的主要角色。已鉴定并分类了多种5-HT受体亚型，并且出现了广泛的5-HT药理学。特别是，已证明5-HT对心血管系统、中枢神经系统（CNS）和胃肠道（GI）有显著作用，并且已开发出选择性模拟或阻断其作用的重要配体。此外，还开发了释放5-HT的药物以及其他阻止其摄取的药物。本简要综述重点关注至少部分具有临床相关性的5-HT激动剂和拮抗剂的药理学。
