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超越特异性:血清素及血清素能治疗对心理生物功能障碍的影响

Beyond specificity: effects of serotonin and serotonergic treatments on psychobiological dysfunction.

作者信息

Dubovsky S L, Thomas M

机构信息

Department of Psychiatry, University of Colorado School of Medicine, Denver, USA.

出版信息

J Psychosom Res. 1995 May;39(4):429-44. doi: 10.1016/0022-3999(94)00043-5.

Abstract

Serotonin is a ubiquitous neurotransmitter with widespread projections that provide for the involvement of serotonin in the regulation of many biological and psychological functions. A variety of serotonin receptor subtypes exist that mediate overlapping psychobiological functions and that are targets for a new generation of medications. Although these new generation medications appear to possess great biochemical specificity, their actions extend to many psychiatric disorders, reflecting the many interactions of serotonergic subsystems.

摘要

血清素是一种广泛存在的神经递质,其投射广泛,使得血清素参与到许多生物和心理功能的调节中。存在多种血清素受体亚型,它们介导重叠的心理生物学功能,并且是新一代药物的作用靶点。尽管这些新一代药物似乎具有很高的生化特异性,但其作用涉及多种精神障碍,这反映了血清素能子系统的诸多相互作用。

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