Keung Y K, Kaplan B, Douer D
Division of Hematology, University of Southern California, Los Angeles 90033.
Leuk Lymphoma. 1994 Jun;14(1-2):181-4. doi: 10.3109/10428199409049666.
We report here a rare case of biphenotypic M0 acute myeloid leukemia (AML) associated with trisomy 4. The literature of trisomy 4 in acute leukemia was reviewed. M2 and M4 AML are the most common FAB subtypes associated with trisomy 4. The clinical course of this entity is generally comparable with other non-trisomy 4 cases of AML. Despite the speculation made when first described, no specific environmental toxin has been found to be associated with this entity. C-kit oncogene has been mapped to chromosome 4 recently, and the role of this proto-oncogene in leukemogenesis of trisomy 4 associated leukemia should be further investigated.
我们在此报告一例罕见的伴有4号染色体三体的双表型M0急性髓系白血病（AML）。对急性白血病中4号染色体三体的文献进行了综述。M2和M4 AML是与4号染色体三体相关的最常见FAB亚型。该疾病实体的临床病程通常与其他非4号染色体三体的AML病例相当。尽管在首次描述时进行了推测，但尚未发现有特定环境毒素与该疾病实体相关。C-kit原癌基因最近已被定位到4号染色体，该原癌基因在4号染色体三体相关白血病发生中的作用应进一步研究。
