以4号染色体三体作为唯一细胞遗传学异常的急性模糊谱系白血病：一例报告及文献复习

Moraveji S, Torabi A, Nahleh Z, Farrag S, Gaur S

Department of Internal Medicine, Texas Tech University, Paul L. Foster School of Medicine, 4801 Alberta Avenue, El Paso, TX 79905, USA.

Department of Pathology, Texas Tech University, Paul L. Foster School of Medicine, 4801 Alberta Avenue El Paso, TX 79905, USA.

Leuk Res Rep. 2014 May 2;3(2):33-5. doi: 10.1016/j.lrr.2014.04.003. eCollection 2014.

We describe a patient with acute leukemia of ambiguous lineage who had trisomy 4 as the sole cytogenetic abnormality. Clinical, pathological, immunophenotypic and molecular features are presented and compared with the previous 4 published cases. Over expression of c-kit, which is localized to chromosome 4, was documented on the leukemic blasts. Prognosis seems to be poor. Treatment with acute lymphoblastic leukemia like regimens seems to be superior compared to acute myeloid leukemia like regimens and allogeneic stem cell transplant is recommended after achieving remission.

我们描述了一名具有模糊谱系急性白血病的患者，其唯一的细胞遗传学异常为4号染色体三体。呈现了该患者的临床、病理、免疫表型和分子特征，并与之前发表的4例病例进行了比较。在白血病原始细胞上记录到位于4号染色体的c-kit过表达。预后似乎较差。与急性髓系白血病样方案相比，采用急性淋巴细胞白血病样方案进行治疗似乎更具优势，建议在缓解后进行异基因干细胞移植。