10号染色体三体与急性髓系白血病
Trisomy 10 and acute myeloid leukemia.
作者信息
Czepulkowski Barbara, Powell Anthony R, Pagliuca Anthony, Mufti Ghulan J
机构信息
Cytogenetics Department, Leukemia Sciences, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK.
出版信息
Cancer Genet Cytogenet. 2002 Apr 1;134(1):81-3. doi: 10.1016/s0165-4608(01)00593-3.
We report the second case of trisomy 10 as the sole abnormality in acute erythroblastic leukemia (AML M6). Trisomy 10 is a rare recurring numerical chromosomal abnormality is probably linked to a myeloblast subset with CD7+ and CD33+ immunophenotype. Most of the 15 cases reported to date in the literature have been M0, M1, or M2, with one showing AML M6 morphology.
我们报告了第二例10号染色体三体作为急性红白血病（AML M6）唯一异常的病例。10号染色体三体是一种罕见的复发性染色体数目异常，可能与具有CD7 +和CD33 +免疫表型的成髓细胞亚群有关。文献中迄今报道的15例病例大多数为M0、M1或M2型，其中一例显示为AML M6形态。
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