Graff J M, Thies R S, Song J J, Celeste A J, Melton D A
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
Cell. 1994 Oct 7;79(1):169-79. doi: 10.1016/0092-8674(94)90409-x.
We report the isolation of a Xenopus BMP receptor that is expressed maternally in the appropriate location to play a role in mesoderm induction. This receptor binds both BMP-2 and BMP-4 with high affinity. A truncated form of this BMP receptor specifically blocks BMP-4 signaling. Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm. Contrary to the popularly held view that ventral is the ground state for all mesoderm, our results suggest that formation of ventral mesoderm requires an active signal and that, in the absence of this ventral signal, dorsal mesoderm is formed.
我们报道了一种非洲爪蟾骨形态发生蛋白（BMP）受体的分离，该受体在胚胎发育早期母源表达于适当位置，对中胚层诱导起作用。这种受体能高亲和力地结合BMP-2和BMP-4。该BMP受体的一种截短形式能特异性阻断BMP-4信号传导。在胚胎发生过程中表达这种截短的BMP受体可使腹侧中胚层转化为背侧中胚层。与普遍认为腹侧是所有中胚层的基础状态的观点相反，我们的结果表明腹侧中胚层的形成需要一个活跃信号，并且在没有这种腹侧信号的情况下，背侧中胚层会形成。
