Holopainen I E, Korpilahti P, Juottonen K, Lang H, Sillanpää M
Department of Pediatric Neurology, University Hospital of Turku, University of Turku, Finland.
J Child Neurol. 1998 Apr;13(4):178-83. doi: 10.1177/088307389801300406.
The auditory event-related potential waveform termed "mismatch negativity" was examined in 12 mentally retarded children with delayed development of speech and language (aged 5-8 years) and in 13 children with developmental dysphasia (aged 5-9 years). The mismatch negativity waves were elicited with pure sine-wave tone stimuli using the oddball paradigm. We measured the peak latency and peak amplitude of mismatch negativity responses to frequency (500/553 Hz) difference. The mismatch negativity patterns were compared with those of 10 children with normal development of linguistic skills (aged 5-9 years). In both the mentally retarded and dysphasic groups, the peak amplitude of the frequency mismatch negativity was significantly attenuated when compared with the control group, but no significant difference was observed between the mentally retarded and dysphasic groups. Attenuated frequency mismatch negativity was related to impairment of linguistic skills irrespective of the child's cognitive skills. Because the mismatch negativity response reflects central auditory processing and is modal specific for auditory stimuli, this change-specific response can serve as an objective tool to elucidate central auditory deficits in children.
对12名语言和言语发育迟缓的智障儿童（5 - 8岁）以及13名发育性言语障碍儿童（5 - 9岁）进行了名为“失配负波”的听觉事件相关电位波形检测。采用奇偶数范式，用纯正弦波音调刺激引出失配负波。我们测量了对频率（500/553赫兹）差异的失配负反应的峰潜伏期和峰振幅。将失配负波模式与10名语言技能发育正常的儿童（5 - 9岁）的模式进行了比较。在智障组和言语障碍组中，与对照组相比，频率失配负波的峰振幅均显著减弱，但智障组和言语障碍组之间未观察到显著差异。频率失配负波减弱与语言技能受损有关，而与儿童的认知技能无关。由于失配负反应反映了中枢听觉处理，并且对听觉刺激具有模式特异性，这种特异性变化反应可作为阐明儿童中枢听觉缺陷的客观工具。
