短暂性全面性遗忘症期间视觉P300的降低。

Reduction of visual P300 during transient global amnesia.

作者信息

Bokura H, Yamaguchi S, Tsuchiya H, Yamashita K, Kobayashi S

机构信息

Third Division of Internal Medicine, Shimane Medical University, Izumo, Japan.

出版信息

Electroencephalogr Clin Neurophysiol. 1994 Sep;92(5):422-5. doi: 10.1016/0168-5597(94)90019-1.

DOI:10.1016/0168-5597(94)90019-1

PMID:7523086

Abstract

Transient global amnesia (TGA) is a syndrome of selective loss of recent memory without other neurological deficits. Auditory and visual P300s were recorded during and after TGA to investigate the contribution of the short-term memory system to P300 generation. The auditory P300 during TGA was comparable to that recorded 1 week and 9 months after TGA. In contrast to the auditory modality, the visual target P300 was reduced in amplitude during TGA and at 1 week after the attack. The P300 to novel visual stimuli was also reduced during TGA. Both target and novelty visual P300 recovered by 9 months after TGA. The results support the notion that the neuronal networks responsible for P300 generation are modality dependent and that brain structures perfused by the posterior circulation are involved in visual P300 generation.

摘要

短暂性全面性遗忘症（TGA）是一种近期记忆选择性丧失且无其他神经功能缺损的综合征。在TGA发作期间及之后记录听觉和视觉P300，以研究短期记忆系统对P300产生的作用。TGA发作期间的听觉P300与TGA发作1周和9个月后记录的结果相当。与听觉模式不同，视觉目标P300在TGA发作期间及发作后1周时波幅降低。TGA发作期间对新视觉刺激的P300也降低。目标视觉P300和新奇视觉P300在TGA发作9个月后均恢复。这些结果支持以下观点，即负责产生P300的神经网络具有模式依赖性，且后循环供血的脑结构参与视觉P300的产生。