Polich J, Squire L R
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
Electroencephalogr Clin Neurophysiol. 1993 Jun;86(6):408-17. doi: 10.1016/0013-4694(93)90136-j.
P3(00) event-related brain potentials (ERPs) were recorded using auditory and visual stimuli from 5 amnesic patients with confirmed (n = 4) or suspected (n = 1) bilateral damage to the hippocampal formation without skull defects. Four normal control subjects were matched to each amnesic patient with respect to age, sex, education, and IQ subtest scores (n = 20 total controls). All 5 amnesic patients exhibited ERPs, and no reliable differences in P3 amplitude or latency could be detected between the patients and the control subjects in either modality. The findings indicate that the hippocampal formation does not contribute significantly to the scalp-recorded P3 from auditory and visual target stimuli, a conclusion also supported by additional recent findings from studies of patients with extensive bilateral medial temporal lobe damage studies. The significance of the P3 component for cognitive processing is discussed.
使用听觉和视觉刺激记录了5名失忆症患者的P3（00）事件相关脑电位（ERP），这些患者确诊（n = 4）或疑似（n = 1）双侧海马结构受损且无颅骨缺损。为每位失忆症患者匹配了4名正常对照受试者，在年龄、性别、教育程度和智商子测试分数方面进行了匹配（共20名对照受试者）。所有５名失忆症患者均表现出ERP，在两种模式下，患者与对照受试者之间均未检测到P3波幅或潜伏期的可靠差异。研究结果表明，海马结构对听觉和视觉目标刺激在头皮记录的P3没有显著贡献，这一结论也得到了近期对广泛双侧内侧颞叶损伤患者研究的其他发现的支持。文中讨论了P3成分对认知加工的意义。
