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Identification of a ToxR-activated gene, tagE, that lies within the accessory colonization factor gene cluster of Vibrio cholerae O395.

作者信息

Kovach M E, Hughes K J, Everiss K D, Peterson K M

机构信息

Department of Microbiology and Immunology, Louisiana State University Medical Center-Shreveport 71130-3932.

出版信息

Gene. 1994 Oct 11;148(1):91-5. doi: 10.1016/0378-1119(94)90239-9.

DOI:10.1016/0378-1119(94)90239-9
PMID:7523253
Abstract

The nucleotide (nt) sequence has been determined for a Vibrio cholerae ToxR-activated gene designated tagE that is located within a cluster of genes required for efficient intestinal colonization. The tagE gene encompasses 909 nt and is predicted to encode a 303-amino-acid (aa) protein with an estimated molecular mass of 34,468 Da. Computer-assisted similarity searches revealed that TagE possesses aa sequence similarity with Escherichia coli OrfU and Staphylococcus simulans lysostaphin, two proteins that are involved in cell-wall biosynthesis and peptidoglycan degradation, respectively. The role, if any, that TagE plays in the accessory colonization factor phenotype is currently under investigation.

摘要

相似文献

1
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