Williams D E
Department of Biological Sciences, Immunex Research and Development Corporation, Seattle, Washington 98101.
J Clin Immunol. 1994 Jul;14(4):215-23. doi: 10.1007/BF01552307.
Hematopoiesis is regulated in a very precise fashion by a balance between both positive and negative growth factor signals in the hematopoietic microenvironment. Many of these growth factor signals have been identified and are available as recombinant proteins. At the present time, the approved uses for hematopoietic growth factors involve their use to facilitate blood cell production in situations of hematopoietic suppression or in cases where endogenous growth factor production is inappropriately low. Recent studies with the hematopoietic growth factors are looking at innovative strategies for their use and new clinical situations in which to evaluate their effectiveness. This review looks at some of these new uses for hematopoietic growth factors.
造血作用是由造血微环境中正负生长因子信号之间的平衡以非常精确的方式调节的。许多这些生长因子信号已被识别出来，并可作为重组蛋白获得。目前，造血生长因子的批准用途包括在造血抑制情况下或内源性生长因子产生异常低的情况下用于促进血细胞生成。最近关于造血生长因子的研究正在探索其使用的创新策略以及评估其有效性的新临床情况。这篇综述探讨了造血生长因子的一些新用途。
