柠檬草（香茅）在沙门氏菌突变试验中对各种已知诱变剂的抗诱变作用。

Antimutagenicity of lemon grass (Cymbopogon citratus Stapf) to various known mutagens in salmonella mutation assay.

作者信息

Vinitketkumnuen U, Puatanachokchai R, Kongtawelert P, Lertprasertsuke N, Matsushima T

机构信息

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand.

出版信息

Mutat Res. 1994 Nov;341(1):71-5. doi: 10.1016/0165-1218(94)90025-6.

DOI:10.1016/0165-1218(94)90025-6

PMID:7523944

Abstract

Lemon grass (Cymbopogon citratus Stapf) was extracted with 80% ethanol. The extract was not found to be mutagenic in the Salmonella mutation test with or without metabolic activation. However, the extract was found to possess antimutagenic properties towards chemical-induced mutation in Salmonella typhimurium strains TA98 and TA100. Mutagenicity of AFB1, Trp-P-1, Trp-P-2, Glu-P-1, Glu-P-2, IQ, MNNG and AF-2, was inhibited by the extract of lemon grass in a dose-dependent manner, but no effect was found on the mutagenic activity of benzo[a]pyrene.

摘要

柠檬草（香茅）用80%乙醇进行提取。在有或无代谢活化的情况下，该提取物在沙门氏菌突变试验中未表现出致突变性。然而，该提取物对鼠伤寒沙门氏菌TA98和TA100菌株中化学诱导的突变具有抗诱变特性。柠檬草提取物以剂量依赖的方式抑制黄曲霉毒素B1、Trp-P-1、Trp-P-2、Glu-P-1、Glu-P-2、IQ、MNNG和AF-2的致突变性，但对苯并[a]芘的诱变活性没有影响。