Hinson J P, Purbrick A, Cameron L A, Kapas S
Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, London, UK.
Neuropeptides. 1994 Jun;26(6):391-7. doi: 10.1016/0143-4179(94)90024-8.
There is much evidence to suggest that glucocorticoid secretion may be influenced by the splanchnic innervation to the adrenal gland, and that this effect may be mediated by neuropeptides. The present studies investigated the effects of several neuropeptides on corticosterone secretion by the intact perfused rat adrenal gland in situ. Both vasoactive intestinal polypeptide and Met-enkephalin caused a dose-dependent increase in corticosterone secretion, with a maximum response of 450% and 370% increment in corticosterone respectively. Of the other peptides tested, Leu-enkephalin, substance P and neurotensin all stimulated corticosterone secretion, with a maximum response of around 160% increase in each case. Neuropeptide Y on the other hand, had only a minor effect, which was only apparent over a small dose range. These results support the theory that adrenal neuropeptides may have a role in the regulation of glucocorticoid secretion.
有大量证据表明，糖皮质激素的分泌可能受肾上腺内脏神经支配的影响，且这种作用可能由神经肽介导。本研究调查了几种神经肽对完整原位灌注大鼠肾上腺皮质酮分泌的影响。血管活性肠肽和甲硫氨酸脑啡肽均引起皮质酮分泌呈剂量依赖性增加，皮质酮的最大反应分别增加450%和370%。在测试的其他肽中，亮氨酸脑啡肽、P物质和神经降压素均刺激皮质酮分泌，每种情况下最大反应约增加160%。另一方面，神经肽Y只有轻微作用，且仅在小剂量范围内明显。这些结果支持肾上腺神经肽可能在糖皮质激素分泌调节中起作用这一理论。
