Evander E, Wollmer P, Valind S, Sörnmo L, John J, Jonson B
Department of Clinical Physiology, University of Lund, Malmö, Sweden.
J Appl Physiol (1985). 1994 Jul;77(1):190-6. doi: 10.1152/jappl.1994.77.1.190.
We measured the pulmonary clearance of technetium-99m-labeled diethylenetriamine pentaacetatic acid (99mTc-DTPA) for 3 h after perturbation of the surfactant system by administration of the detergent dioctyl sodium sulfosuccinate in aerosol. Forty-two rabbits were anesthetized with pentobarbital sodium. Tracheostomies were performed, and the rabbits were mechanically ventilated. Increasing concentrations of detergent (0.125-2%) or vehicle were given for 5 min, and clearance measurements were performed immediately or 60 min after detergent administration. No animals developed respiratory distress. After vehicle, the clearance was monoexponential with a half-life of 153 min. Detergent induced a biexponential clearance with a rapidly clearing additional pool of radioactivity with a half-life of 5-15 min. The relative amount of radioactivity clearing rapidly increased with detergent concentration. The detergent effect was partly reversible. We conclude that detergent induces a biexponential clearance of 99mTc-DTPA by accelerating the transfer of tracer across the alveolocapillary barrier in a proportion of lung units in a dose-related manner.
我们通过雾化给予去污剂磺基琥珀酸二辛酯钠来扰动表面活性剂系统，然后测量了99m锝标记的二乙烯三胺五乙酸（99mTc-DTPA）在3小时内的肺清除率。42只兔子用戊巴比妥钠麻醉。进行气管切开术，然后对兔子进行机械通气。给予浓度递增的去污剂（0.125 - 2%）或赋形剂5分钟，在给予去污剂后立即或60分钟后进行清除率测量。没有动物出现呼吸窘迫。给予赋形剂后，清除率呈单指数形式，半衰期为153分钟。去污剂诱导出双指数清除，有一个放射性快速清除的额外池，半衰期为5 - 15分钟。快速清除的放射性相对量随去污剂浓度增加。去污剂的作用部分是可逆的。我们得出结论，去污剂通过以剂量相关的方式加速示踪剂在一部分肺单位中穿过肺泡毛细血管屏障的转运，从而诱导99mTc-DTPA的双指数清除。
