Nilsson K, Wollmer P
Dept of Clinical Physiology, University of Lund, Sweden.
Eur Respir J. 1993 Apr;6(4):505-8.
We measured the pulmonary clearance of inhaled 99mTc-diethylenetriamine penta-acetic acid (DTPA), 99mTc-sestamibi and 99mTc-dimethyliminodiacetic acid (HIDA) in normal rabbits, and rabbits with surfactant dysfunction induced by the detergent dioctyl sodium sulfosuccinate. The tracers differ widely in lipid/water partition coefficients, but have similar molecular radius and weight. Five animals in each group received the detergent in aerosol, and the other five a vehicle aerosol, before the administration of the tracer. Pulmonary clearance of the tracers was measured with a gamma camera. The half-life of 99mTc-DTPA was 94 +/- 16 min in normal lungs, and 10 +/- 1 min after detergent administration (p < 0.001). The half-life for 99mTc-sestamibi was 45 +/- 4 min and 39 +/- 4 min, respectively, (p < 0.05). There was no significant difference between the half-life of 99mTc-HIDA in normal lungs and in lungs with surfactant dysfunction. The half-life was 20 +/- 3 min and 17 +/- 2 min, respectively. The results indicate that the clearance rate limiting factors for the alveolocapillary transfer of water and lipid soluble substances are not the same. Surfactant dysfunction affects the transfer of water soluble substances (99mTc-DTPA) but not of substances with high lipid solubility (99mTc-HIDA).
我们测量了正常家兔以及由磺基琥珀酸二辛酯钠诱导产生表面活性剂功能障碍的家兔吸入99m锝-二乙烯三胺五乙酸（DTPA）、99m锝-甲氧基异丁基异腈和99m锝-二甲基亚氨基二乙酸（HIDA）后的肺清除率。这些示踪剂的脂/水分配系数差异很大，但分子半径和分子量相似。每组五只动物在给予示踪剂前接受气雾剂形式的去污剂，另外五只接受载体气雾剂。用γ相机测量示踪剂的肺清除率。99m锝-DTPA在正常肺中的半衰期为94±16分钟，给予去污剂后为10±1分钟（p<0.001）。99m锝-甲氧基异丁基异腈的半衰期分别为45±4分钟和39±4分钟（p<0.05）。99m锝-HIDA在正常肺和表面活性剂功能障碍肺中的半衰期无显著差异，分别为20±3分钟和17±2分钟。结果表明，水和脂溶性物质的肺泡-毛细血管转运的清除率限制因素不同。表面活性剂功能障碍影响水溶性物质（99m锝-DTPA）的转运，但不影响高脂溶性物质（99m锝-HIDA）的转运。
