Orito E, Mizokami M, Mizoguchi N, Ohba K, Tohnai M, Yamanaka H, Oguri T, Hirashima N, Koide T, Kano H
Second Department of Internal Medicine, Nagoya City University Medical School, Japan.
J Hepatol. 1994 Jul;21(1):130-2. doi: 10.1016/s0168-8278(94)80149-5.
To determine whether serological typing of hepatitis C virus correlated with the response to interferon-alpha therapy, hepatitis C virus serotypes were determined by subtype-specific antibody to NS4 polypeptide by enzyme-linked immunosorbent assay in 55 Japanese patients with chronic active hepatitis C who subsequently received recombinant interferon-alpha 2a therapy. Response to interferon-alpha was defined as complete and sustained (n = 12), complete response followed by relapse (n = 26), and no response (n = 17). There was no difference in the clinical biochemical parameters between these patients groups. However, a higher proportion (50.0%) of patients with hepatitis C virus serotype II showed complete and sustained response to interferon-alpha, compared to serotype I (11.1%, p < 0.01). These data indicate that this simple hepatitis C virus serotyping assay is a useful predictor of response to interferon-alpha therapy in patients with chronic hepatitis C virus infection.
为了确定丙型肝炎病毒的血清学分型是否与α干扰素治疗反应相关，采用酶联免疫吸附试验，通过针对NS4多肽的亚型特异性抗体，对55例日本慢性活动性丙型肝炎患者进行丙型肝炎病毒血清学分型，这些患者随后接受了重组α干扰素-2a治疗。α干扰素反应定义为完全缓解且持续缓解（n = 12）、完全缓解后复发（n = 26）和无反应（n = 17）。这些患者组之间的临床生化参数没有差异。然而，与I型血清型患者（11.1%，p < 0.01）相比，II型丙型肝炎病毒血清型患者对α干扰素表现出完全缓解且持续缓解的比例更高（50.0%）。这些数据表明，这种简单的丙型肝炎病毒血清学分型检测是慢性丙型肝炎病毒感染患者对α干扰素治疗反应的有用预测指标。
