[牛磺胆酸盐诱导的胃黏膜屏障损伤中胃黏膜对致癌物的通透性]
[Permeability of the gastric mucosa for carcinogens in taurocholate-induced injury of the mucosa barrier].
作者信息
Schiessel R, Starlinger M, Hofbauer F, Bratusch-Marrein P
出版信息
Chir Forum Exp Klin Forsch. 1978(1978):239-42.
PMID:752592
Abstract
The influence of taurocholate-induced damage of the gastric mucosal barrier on transmucosal movement of methyl-N-nitro-N-nitrosoguanidine (MNNG) was investigated on dogs with Heidenhain pouches. We also investigated whether or not MNNG influences the mucosal barrier. The results of 10 experiments revealed no effect of MNNG on the mucosal barrier, but a significant time-related decrease of intraluminal MNNG concentration in the presence of taurocholate.
摘要
在具有海登海因小胃的犬身上，研究了牛磺胆酸盐诱导的胃黏膜屏障损伤对甲基 - N - 硝基 - N - 亚硝基胍（MNNG）跨黏膜转运的影响。我们还研究了MNNG是否影响黏膜屏障。10项实验的结果显示，MNNG对黏膜屏障无影响，但在存在牛磺胆酸盐的情况下，管腔内MNNG浓度出现了与时间相关的显著下降。
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