Stoilov L M, Mullenders L H, Natarajan A T
MGC Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, The Netherlands.
Mutat Res. 1994 Dec 1;311(2):169-74. doi: 10.1016/0027-5107(94)90174-0.
The effect of caffeine on radiation-induced chromosomal aberrations and DNA strand breaks in unstimulated human lymphocytes was investigated. When present prior to and during the radiation exposure, caffeine treatment was found to cause either potentiation or protection against induction of chromosomal aberrations depending on the concentration and temperature. When the nucleoid sedimentation technique was applied, enhancement or reduction of radiation-induced DNA strand breaks by caffeine was also found to be dependent on temperature and caffeine concentration. It is proposed that caffeine, in addition to its suspected ability to influence DNA repair, can also influence the induction of DNA damage, leading to alterations in the yield of chromosomal aberrations.
研究了咖啡因对未受刺激的人淋巴细胞中辐射诱导的染色体畸变和DNA链断裂的影响。当在辐射暴露之前和期间存在时，发现咖啡因处理根据浓度和温度会导致对染色体畸变诱导的增强或保护作用。当应用核仁沉降技术时，还发现咖啡因对辐射诱导的DNA链断裂的增强或减少也取决于温度和咖啡因浓度。有人提出，咖啡因除了其影响DNA修复的可疑能力外，还能影响DNA损伤的诱导，导致染色体畸变率的改变。
