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在一氧化氮合酶抑制剂存在的情况下，大鼠海马体中长时程增强（LTP）和长时程抑制（LTD）的诱导。

Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor.

作者信息

Cummings J A, Nicola S M, Malenka R C

机构信息

Graduate Program in Neuroscience, University of California at San Francisco, Langley Porter Psychiatric Institute 94143-0984.

出版信息

Neurosci Lett. 1994 Jul 18;176(1):110-4. doi: 10.1016/0304-3940(94)90883-4.

DOI:10.1016/0304-3940(94)90883-4
PMID:7526298
Abstract

Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP and LTD. In this study we show that normal LTP and LTD can be induced in rat hippocampal slices incubated in the NO synthase inhibitor L-NG-nitroarginine (NOArg) (100 microM). A test of NMDA-stimulated cGMP production demonstrated that incubation of slices in 100 microM NOArg effectively inhibited NO synthase. Our results suggest that NO synthase activity may not be required for the generation of LTP or LTD in CA1 of rat hippocampus.

摘要

最近的几项研究表明，一氧化氮（NO）生成在海马体的长时程增强（LTP）和长时程抑制（LTD）中起关键作用。在本研究中，我们发现，在一氧化氮合酶抑制剂L-NG-硝基精氨酸（NOArg，100微摩尔）中孵育的大鼠海马切片中可诱导出正常的LTP和LTD。一项对NMDA刺激的环磷酸鸟苷（cGMP）生成的测试表明，将切片在100微摩尔NOArg中孵育可有效抑制一氧化氮合酶。我们的结果表明，大鼠海马体CA1区LTP或LTD的产生可能不需要一氧化氮合酶活性。

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Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor.在一氧化氮合酶抑制剂存在的情况下，大鼠海马体中长时程增强（LTP）和长时程抑制（LTD）的诱导。
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