Haupts M, Calabrese P, Babinsky R, Gehlen W, Markowitsch H J
Neurologische Universitätsklinik, Krankenhaus Bochum-Langendreer.
Schweiz Arch Neurol Psychiatr (1985). 1994;145(1):14-9.
35 multiple sclerosis patients and 30 matched healthy controls were investigated for mnestic problems using a German everyday memory test. The objects were both the description of structural characteristics of disturbances and "ecological validity" to meet rehabilitative issues prospectively. In the MS group, impairments were found mainly in the memory domain under delayed recall conditions of complex material. The processing of these tasks may be especially sensitive against fiber tract lesions. While discrete lesions, mostly found in patients with relapsing-remitting courses, inconsistently lead to partial memory disturbances, global mnestic deficits are to be expected in confluent lesion patterns exceeding a critical "threshold of cerebral tolerance." The latter characterises mostly patients with chronic progressive disease courses.
35名多发性硬化症患者和30名相匹配的健康对照者接受了一项德国日常记忆测试，以调查记忆问题。目的在于描述障碍的结构特征并实现“生态效度”，以便前瞻性地解决康复问题。在多发性硬化症组中，主要在复杂材料的延迟回忆条件下的记忆领域发现了损伤。这些任务的处理可能对纤维束病变特别敏感。虽然离散性病变大多见于复发缓解型病程的患者，并不一致地导致部分记忆障碍，但在超过关键的“脑耐受阈值”的融合性病变模式中，预计会出现全面的记忆缺陷。后者主要表征慢性进展型病程的患者。
