Man W K, Cassidy M J, Spencer J
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Agents Actions. 1994 Jun;41 Spec No:C93-4. doi: 10.1007/BF02007782.
Gastric secretion was measured in patients with chronic renal failure (CRF) on continuous ambulatory peritoneal dialysis (CAPD), non-uraemic patients with a duodenal ulcer (DU), and healthy volunteers (HV). Basal acid outputs were not significantly different in the three groups. Under pentagastrin stimulation, acid secretion was lower in CAPD patients than in DU patients (p < 0.02) but not different from HV controls. Between CAPD and DU, basal histamine secretion measured in the gastric juice was not different, but the concentration in blood plasma was significantly lower in the CAPD group (p < 0.05). Under pentagastrin stimulation, gastric histamine output and plasma histamine concentration were significantly lower in CAPD patients (p < 0.05, respectively). Both basal and pentagastrin-stimulated gastric acid and histamine outputs were directly related. These results suggest that CAPD patients do not have an increased risk of developing DU, but may need acid blockade if they are treated for hyperphosphataemia with aluminium containing drugs.
对接受持续非卧床腹膜透析（CAPD）的慢性肾衰竭（CRF）患者、患有十二指肠溃疡（DU）的非尿毒症患者以及健康志愿者（HV）进行了胃液分泌测量。三组的基础酸排量无显著差异。在五肽胃泌素刺激下，CAPD患者的胃酸分泌低于DU患者（p < 0.02），但与HV对照组无差异。在CAPD组和DU组之间，胃液中测得的基础组胺分泌无差异，但CAPD组血浆中的组胺浓度显著更低（p < 0.05）。在五肽胃泌素刺激下，CAPD患者的胃组胺排出量和血浆组胺浓度显著更低（分别为p < 0.05）。基础和五肽胃泌素刺激后的胃酸和组胺排出量均直接相关。这些结果表明，CAPD患者发生DU的风险并未增加，但如果他们使用含铝药物治疗高磷血症，则可能需要进行酸阻断。
