Dermicheva S G, Dosanov K Sh, Koronelli T V
Probl Tuberk. 1993(3):4-7.
The changes in the inclusion of 3H-phenylalanine, methyl-3H-thymidine, [2-14C]-thymidine and [5-3H]-uridine in the cells of pathogenic M. bovis-8, opportunistic M. fortuitum and saprophitic M. phlei, M. B-5 were comparatively investigated in introduction of 0.01 and 0.10% concentrations of the drug DP-2. It is shown that 0.10% DP-2 completely stops the radionuclides supply to the cells. It is suggested that the target of the drug may exist in the sphere of amino acid biosynthesis. The presence of DP-2 is capable of disturbing transport of substances to the cells.
在引入浓度为0.01%和0.10%的药物DP - 2时,对致病性牛分枝杆菌 - 8、机会性偶然分枝杆菌以及腐生性草分枝杆菌、B - 5分枝杆菌细胞中³H - 苯丙氨酸、甲基 - ³H - 胸腺嘧啶核苷、[2 - ¹⁴C] - 胸腺嘧啶核苷和[5 - ³H] - 尿苷的掺入变化进行了比较研究。结果表明,0.10%的DP - 2完全阻断了放射性核素向细胞的供应。推测该药物的作用靶点可能存在于氨基酸生物合成领域。DP - 2的存在能够干扰物质向细胞的转运。