Failla D M, Pankey G A
Department of Internal Medicine, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, Louisiana.
Drugs. 1994 Aug;48(2):172-8. doi: 10.2165/00003495-199448020-00004.
Skin and skin structure infections appear in a variety of ways with multiple aetiologies. Optimum therapy is accomplished with a good understanding of both skin anatomy and common resident or transient bacterial flora present on the skin surface. Primary and secondary infections occur in both immunocompetent and immunocompromised patients, each of which require unique decision-making skills on the part of the prescriber. Deciding when culture and sensitivity should be performed or therapy should be begun empirically is often difficult and can be frustrating. This is complicated by the ever-increasing number of antimicrobial agents available today and their variable costs. Choosing the best antibiotic agent, based on evidence of which is the most effective agent for a particular lesion, the easiest dosage schedule and the most economical drug, is a goal that will best serve both the patient and the physician.
皮肤及皮肤结构感染有多种表现形式，病因也多种多样。要实现最佳治疗，需要充分了解皮肤解剖结构以及皮肤表面常见的常驻或暂住细菌菌群。免疫功能正常和免疫功能低下的患者都会发生原发性和继发性感染，这就要求处方医生具备独特的决策能力。决定何时应进行培养和药敏试验，或何时应开始经验性治疗，往往很困难，也可能令人沮丧。如今可用的抗菌药物数量不断增加，且成本各异，这使情况变得更加复杂。根据哪种药物对特定病变最有效、给药方案最简单以及药物最经济的证据来选择最佳抗生素，是一个对患者和医生都最有利的目标。
