Nathwani D
Infection and Immunodeficiency Unit, Tayside University Hospitals Trust, Dundee, UK.
Chemotherapy. 2001;47 Suppl 1:17-23. doi: 10.1159/000048564.
In a study in Scotland, skin and soft tissue infections (SSTIs) accounted for 10% of hospitalizations, with mean stays of approximately 5 days, and were the second most common reason for hospital-based intravenous antibiotic therapy lasting more than 48 h. A total of 125 patients with SSTIs were recently treated using an outpatient parenteral antibiotic therapy (OPAT) service. The patients received intravenous antibiotic therapy for a mean duration of 5.32 days. The two primary agents administered were once-daily ceftriaxone and teicoplanin. Of the 125 patients, 123 (98.4%) were cured or improved; 2 worsened and required surgery. Patient satisfaction was very high. OPAT saved the inpatient facility 665 bed days. Economic benefits were realized despite use of more expensive agents. Data indicate that if the hospital stay of patients with SSTIs were reduced by only 1 day, savings would amount to pound(1/2)-1 million per year. OPAT is a feasible alternative to inpatient management of SSTIs and may safely, effectively and cost-effectively reduce the number of hospital days for these infections.
在苏格兰的一项研究中，皮肤和软组织感染（SSTIs）占住院病例的10%，平均住院时间约为5天，并且是医院内静脉抗生素治疗持续超过48小时的第二大常见原因。最近共有125例皮肤和软组织感染患者接受了门诊胃肠外抗生素治疗（OPAT）服务。这些患者接受静脉抗生素治疗的平均时长为5.32天。使用的两种主要药物是每日一次的头孢曲松和替考拉宁。125例患者中，123例（98.4%）治愈或病情改善；2例病情恶化并需要手术。患者满意度很高。门诊胃肠外抗生素治疗为住院设施节省了665个床位日。尽管使用了更昂贵的药物，但仍实现了经济效益。数据表明，如果皮肤和软组织感染患者的住院时间仅减少1天，每年可节省50万至100万英镑。门诊胃肠外抗生素治疗是皮肤和软组织感染住院管理的一种可行替代方案，并且可以安全、有效且经济高效地减少这些感染的住院天数。
