[Disorders of fetoplacental function in pregnant women with diabetes].

The paper presents the first results obtained as a part of a screening programme of detection of congenital developmental defects of the fetus. Pregnancies with diabetes are one of the risk groups in this respect. We have divided our patients (n = 58) into two groups. In the first there were 28 diabetics in the 15th-16th week of pregnancy. They were examined for alpha-1-fetoprotein (MS AFP) and trophoblast-specific beta-1-glycoprotein (MS SP1): in chosen cases chorionic gonadotropine (MS HCG) was assessed at the same time. The second group were 35 insulin-dependent pregnant diabetics followed-up in Regional Ambulance of Central Bohemia and hospitalized at the First Clinic of Obstetrics and Gynaecology of the First Medical Faculty, whose MS SP1 levels were being assessed (usually in one-week intervals) during the second and third trimester of pregnancy. 21 patients were simultaneously examined for glycated serum proteins. Our study confirmed MS AFP levels of diabetics in the 15th-16th week of pregnancy to be range of low limit of normal values (0.5-1.0 MOM). MS HCG levels in sera of diabetics ranged from 5,000 to 60,000 IU/ml in the 15th-16th week. Comparing glycated serum proteins of women with physiological pregnancies with those of healthy non-pregnant controls we had found no differences. In diabetics the values found in the second and third trimester of pregnancy were increased.