Kinami Y, Kita I, Kojima Y, Takashima S
Division of Cancer Research, Kanazawa Medical University, Japan.
HPB Surg. 1994;8(1):43-7; discussion 47-8. doi: 10.1155/1994/25496.
Changes in serum and intrapancreatic enzyme content and protein synthesis in pancreas were studied in acute oedematous pancreatitis (AOP). Male Wistar rats (n = 111) were divided into 2 groups, controls with a sham operation and those with AOP. Serum amylase levels rose immediately after the procedure causing AOP and then fell gradually, while serum lipase and ribonuclease levels remained higher than control values over 48 h. (p < 0.05, 0.01). Serum deoxyribonuclease (DNase) II levels were unchanged. Intrapancreatic enzyme levels were scarcely affected by AOP. 3H-leucine uptake into pancreatic tissue of rats with AOP was decreased throughout the study (p < 0.001), but some protein synthesis continued. Intrapancreatic enzyme contents are maintained despite diffusion into the blood because the pancreas retain its ability to synthesize enzymes.
在急性水肿性胰腺炎（AOP）中，研究了血清和胰腺内酶含量的变化以及胰腺中的蛋白质合成。将雄性Wistar大鼠（n = 111）分为两组，一组为假手术对照组，另一组为AOP组。导致AOP的手术后血清淀粉酶水平立即升高，然后逐渐下降，而血清脂肪酶和核糖核酸酶水平在48小时内仍高于对照值（p < 0.05，0.01）。血清脱氧核糖核酸酶（DNase）II水平未发生变化。AOP对胰腺内酶水平几乎没有影响。在整个研究过程中，AOP大鼠胰腺组织对3H-亮氨酸的摄取减少（p < 0.001），但仍有一些蛋白质合成。尽管酶扩散到血液中，但胰腺内酶含量仍得以维持，因为胰腺保留了合成酶的能力。
