高脂血症会加重大鼠急性水肿性胰腺炎和急性坏死性胰腺炎的病程。
Hyperlipaemia intensifies the course of acute oedematous and acute necrotising pancreatitis in the rat.
作者信息
Hofbauer B, Friess H, Weber A, Baczako K, Kisling P, Schilling M, Uhl W, Dervenis C, Büchler M W
机构信息
Department of Visceral and Transplantation Surgery, University of Berne, Switzerland.
出版信息
Gut. 1996 May;38(5):753-8. doi: 10.1136/gut.38.5.753.
BACKGROUND
Serum triglyceride concentrations higher than 10 to 20 mmol/l are probably a risk factor for developing acute pancreatitis in humans.
AIMS
To therefore analyse the influence of hyperlipaemia on the course of acute oedematous and acute necrotising pancreatitis in rats.
SUBJECTS
Male Wistar rats were used in all experiments.
METHODS
Six different groups of animals were used: two groups without pancreatitis (controls), two with acute oedematous pancreatitis, and two with acute necrotising pancreatitis. One group from each pair was treated with Triton WR 1339, which induces endogenous hyperlipaemia. Blood samples were taken from all subjects to measure triglyceride, cholesterol, amylase, and lipase. Pancreatic tissue samples were taken and the degree of pancreatic damage was judged microscopically.
RESULTS
In the control groups no significant changes occurred, either in serum enzyme activities or in histology. The hyperlipaemic subgroup of animals with acute oedematous pancreatitis developed significantly higher (p < 0.001) serum amylase activities and a greater degree of histological damage (p < 0.01) than the animals of the non-hyperlipaemic acute oedematous pancreatitis group. In the animals with necrotising pancreatitis, serum lipase activity and the histological degree of pancreatic damage were significantly higher in the hyperlipaemic animals than in the non-hyperlipaemic animals.
CONCLUSION
This study shows that hyperlipaemia intensifies the course of acute oedematous and acute necrotising pancreatitis in rats.
背景
血清甘油三酯浓度高于10至20 mmol/l可能是人类发生急性胰腺炎的一个危险因素。
目的
因此，分析高脂血症对大鼠急性水肿性胰腺炎和急性坏死性胰腺炎病程的影响。
对象
所有实验均使用雄性Wistar大鼠。
方法
使用六组不同的动物：两组无胰腺炎（对照组），两组急性水肿性胰腺炎，两组急性坏死性胰腺炎。每对中的一组用Triton WR 1339处理，其可诱导内源性高脂血症。采集所有受试者的血样以测量甘油三酯、胆固醇、淀粉酶和脂肪酶。采集胰腺组织样本并通过显微镜判断胰腺损伤程度。
结果
在对照组中，血清酶活性和组织学均未发生显著变化。与非高脂血症急性水肿性胰腺炎组的动物相比，急性水肿性胰腺炎动物的高脂血症亚组血清淀粉酶活性显著更高（p < 0.001），组织学损伤程度更大（p < 0.01）。在坏死性胰腺炎动物中，高脂血症动物的血清脂肪酶活性和胰腺损伤的组织学程度显著高于非高脂血症动物。
结论
本研究表明高脂血症会加剧大鼠急性水肿性胰腺炎和急性坏死性胰腺炎的病程。
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