Li C H, Guo F Y, Yue J
First Teaching Hospital, Bethune University of Medical Sciences, Changchun.
Zhonghua Fu Chan Ke Za Zhi. 1994 Jun;29(6):328-9, 380.
Detection of serum antibody of hepatitis C virus (anti-HCV) with ELISA kits was performed in 315 parturients and their newborns. The results indicated that some of the infants, born of mothers infected with HCV were also anti-HCV positive, and a high positive rate of abnormal maternal hepato-function harbored a markedly positive rate of anti-HCV both in mother and newborn and bore a positive correlation to the maternal age. These suggest that besides the five routine tests, anti-HCV should better be determined, especially in mothers with abnormal hepato-function. If possible, in such cases HCV-RNA should be examined by using revert nested polymerase chain reaction technique to determine whether a vertical mother-infant transmission exists.
采用酶联免疫吸附试验（ELISA）试剂盒对315例产妇及其新生儿进行丙型肝炎病毒血清抗体（抗-HCV）检测。结果显示，部分感染HCV母亲所生婴儿抗-HCV也呈阳性，肝功能异常的产妇抗-HCV阳性率较高，且母亲和新生儿抗-HCV阳性率均显著升高，与产妇年龄呈正相关。这些结果提示，除五项常规检查外，最好检测抗-HCV，尤其是肝功能异常的母亲。如有可能，应采用逆转巢式聚合酶链反应技术检测此类病例的HCV-RNA，以确定是否存在母婴垂直传播。
