Grauer M E, Bokemeyer C, Bautsch W, Freund M, Link H
Abteilung Hämatologie und Onkologie, Medizinische Hochschule, Hannover, Germany.
Infection. 1994 Jul-Aug;22(4):283-6. doi: 10.1007/BF01739918.
Invasive fungal infections have become an increasing problem in severely immunocompromised hosts. We here report a case of septicemia, caused by Trichosporon beigelii, an unusual pathogen of systemic infections. This infection was acquired during a period of severe neutropenia after chemotherapy for relapsed acute myelogenous leukemia following allogeneic bone marrow transplantation. The patient recovered from a life-threatening T. beigelii septicemia due to early intensified treatment with amphotericin B and a rapid neutrophil recovery, enhanced by granulocyte colony-stimulating factor (G-CSF). According to the current literature, amphotericin B is the treatment of choice for systemic T. beigelii infections. In patients with severe granulocytopenia, the rapid recovery of neutrophils remains the most important factor for the outcome of this infection.
侵袭性真菌感染在严重免疫功能低下的宿主中已成为一个日益严重的问题。我们在此报告一例由白吉利丝孢酵母引起的败血症病例，白吉利丝孢酵母是一种引起全身感染的罕见病原体。该感染发生在异基因骨髓移植后复发的急性髓性白血病化疗后严重中性粒细胞减少期间。由于早期强化使用两性霉素B治疗以及粒细胞集落刺激因子（G-CSF）促进中性粒细胞快速恢复，患者从危及生命的白吉利丝孢酵母败血症中康复。根据目前的文献，两性霉素B是治疗全身性白吉利丝孢酵母感染的首选药物。在严重粒细胞减少的患者中，中性粒细胞的快速恢复仍然是影响这种感染预后的最重要因素。
