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前列腺的可视化激光消融:初步报告。

Visual laser ablation of the prostate: a preliminary report.

作者信息

Malek R S, Barrett D M, Dilworth J P

机构信息

Department of Urology, Mayo Clinic, Rochester, Minnesota 55905.

出版信息

Mayo Clin Proc. 1995 Jan;70(1):28-32. doi: 10.1016/S0025-6196(11)64661-2.

Abstract

OBJECTIVE

To report our preliminary experience with visual laser ablation of the prostate (VLAP) for treating bladder outlet obstruction caused by benign prostatic hyperplasia (BPH) and to evaluate its short-term outcome.

DESIGN

We reviewed our laser technique in 47 men with symptomatic obstruction caused by BPH who underwent VLAP between July 1992 and April 1993 at our institution, and we compared our results with those reported in the literature.

MATERIAL AND METHODS

Our 47 patients were from 43 to 87 years old (mean, 69.6). The mean pretreatment American Urological Association symptom score was 22, mean peak flow rate was 9.5 mL/s, and mean postvoid residual urinary volume was 136 mL. Neodymium:yttrium-aluminum-garnet laser energy was delivered at the 2-, 4-, 8-, and 10-o'clock positions and, when necessary, to the median lobe by one of two lateral-firing laser probes. All but the first four patients were treated on an outpatient basis, and all patients were catheterized (Foley catheter) for 2 to 10 days after VLAP.

RESULTS

Of the 47 patients, 32 had data pertaining to a mean follow-up of 5 months; they had a mean symptom score of 10, mean peak flow rate of 15.7 mL/s, and mean postvoid residual volume of 63 mL. In 12 patients, data from a mean follow-up of 11 months were available; they had a mean symptom score of 6, mean peak flow rate of 18.8 mL/s, and mean postvoid residual volume of 10 mL. Perioperative complications (myocardial infarction, thrombophlebitis, and epididymitis) in three patients responded to conservative therapy. Urinary retention occurred for 2 to 60 days after initial removal of the Foley catheter in 12 patients, who then had resumption of spontaneous voiding. In three patients who stated their condition was worse postoperatively, conventional transurethral resection of the prostate was done 6 months after VLAP, and a fourth patient had a persistently obstructive bladder neck incised 8 months after VLAP.

CONCLUSION

Our early experience and that reported in the literature indicate that VLAP is a safe and efficacious alternative treatment of obstructive BPH. Although the early results of VLAP rival those of transurethral resection of the prostate, the success rate in treating large prostates should be improved, and long-term results should be assessed to determine the durability of the beneficial effects.

摘要

目的

报告我们使用可视激光前列腺切除术(VLAP)治疗良性前列腺增生(BPH)所致膀胱出口梗阻的初步经验,并评估其短期疗效。

设计

我们回顾了1992年7月至1993年4月在我院接受VLAP治疗的47例因BPH出现症状性梗阻的男性患者的激光技术,并将我们的结果与文献报道的结果进行比较。

材料与方法

我们的47例患者年龄在43至87岁之间(平均69.6岁)。术前美国泌尿外科学会症状评分平均为22分,平均最大尿流率为9.5 mL/s,平均排尿后残余尿量为136 mL。钕:钇铝石榴石激光能量通过两根侧向发射激光探头之一,在2点、4点、8点和10点位置,必要时向中叶发射。除前4例患者外,其余患者均在门诊接受治疗,所有患者在VLAP术后均留置导尿管(Foley导尿管)2至10天。

结果

47例患者中,32例有平均随访5个月的数据;他们的平均症状评分为10分,平均最大尿流率为15.7 mL/s,平均排尿后残余尿量为63 mL。12例患者有平均随访11个月的数据;他们的平均症状评分为6分,平均最大尿流率为18.8 mL/s,平均排尿后残余尿量为10 mL。3例患者的围手术期并发症(心肌梗死、血栓性静脉炎和附睾炎)经保守治疗后好转。12例患者在首次拔除Foley导尿管后2至60天出现尿潴留,随后恢复自主排尿。3例自述术后病情恶化的患者在VLAP术后6个月接受了传统经尿道前列腺切除术,第4例患者在VLAP术后8个月切开了持续梗阻的膀胱颈。

结论

我们的早期经验以及文献报道表明,VLAP是治疗梗阻性BPH的一种安全有效的替代治疗方法。虽然VLAP的早期结果可与经尿道前列腺切除术相媲美,但治疗大前列腺的成功率应进一步提高,且应评估长期结果以确定有益效果的持久性。

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