薄荷醇及相关清凉化合物。

Menthol and related cooling compounds.

作者信息

Eccles R

机构信息

Department of Physiology, University of Wales College of Cardiff, UK.

出版信息

J Pharm Pharmacol. 1994 Aug;46(8):618-30. doi: 10.1111/j.2042-7158.1994.tb03871.x.

DOI:10.1111/j.2042-7158.1994.tb03871.x

PMID:7529306

Abstract

Menthol and related cooling compounds such as 'coolant agent 10', are widely used in products ranging from common cold medications to toothpastes, confectionery, cosmetics and pesticides. The review brings together a range of information on production and chemistry of menthol, and its metabolism, mechanism of action, structure-activity relationships, pharmacology and toxicology. In particular, the coolant action and carminative actions of menthol are discussed in terms of actions on calcium conductance in sensory nerves and smooth muscle. The actions of menthol on the nose, respiratory reflexes, oral cavity, skin and gastrointestinal tract are reviewed.

摘要

薄荷醇及相关的清凉化合物，如“冷却剂10”，广泛应用于从感冒药到牙膏、糖果、化妆品和杀虫剂等各类产品中。这篇综述汇集了一系列关于薄荷醇的生产、化学性质及其代谢、作用机制、构效关系、药理学和毒理学的信息。特别是，从对感觉神经和平滑肌钙电导的作用方面讨论了薄荷醇的清凉作用和祛风作用。综述了薄荷醇对鼻子、呼吸反射、口腔、皮肤和胃肠道的作用。