Abdalla Mohga S, Salem Aliaa Abdelrafea, Hussien Eman Tawfik, Ramadan Shimaa S
Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.
Botany and Microbiology Department, Faculty of Science, Helwan University, Cairo, Egypt.
Sci Rep. 2025 Sep 12;15(1):32463. doi: 10.1038/s41598-025-18314-1.
This research investigates the bioactive properties of essential oils obtained from three medicinal and aromatic species: Mentha canadensis, Corymbia citriodora, and Plectranthus amboinicus. The essential oils were evaluated for antiviral, antioxidant, anticancer, and antidiabetic activities. The gas chromatography-mass spectrometry (GC-MS) examination identified a variety of phytochemical constituents, including thymol, citronellol, and levomenthol. Cytopathic impact studies indicated that M. canadensis and C. citriodora oils attained a maximum of 35.34% suppression of Adeno 7 virus replication. The oils exhibited minimal cytotoxicity in Vero cells, with viability exceeding 97% at concentrations of ≤ 312 µg/mL. P. amboinicus oil had the highest cytotoxicity against H1299 lung cancer cells (IC = 11 µg/mL), indicating significant anticancer efficacy. The antidiabetic effects were evidenced by α-glucosidase inhibition, with P. amboinicus oil displaying the greatest activity (IC = 248.1 µg/mL). The DPPH experiment demonstrated that P. amboinicus exhibited the highest antioxidant activity (IC = 5923 µg/mL). The results highlight the medicinal potential of these essential oils, including P. amboinicus for anticancer, antioxidant and antidiabetic applications, and C. citriodora and M. canadensisfor antiviral purposes. The current work serves about four goals of the sustainable development goals (SDG) as follow: SDG 3: Good Health and Well-being, SDG 12: Responsible Consumption and Production, SDG 9: Industry, Innovation, and Infrastructure and SDG 15: Life on Land.
加拿大薄荷、柠檬桉和食用霍香。对这些精油的抗病毒、抗氧化、抗癌和抗糖尿病活性进行了评估。气相色谱 - 质谱（GC - MS）分析鉴定出多种植物化学成分，包括百里香酚、香茅醇和左旋薄荷醇。细胞病变效应研究表明，加拿大薄荷和柠檬桉精油对腺病毒7型病毒复制的抑制率最高可达35.34%。这些精油在非洲绿猴肾细胞中表现出最小的细胞毒性，在浓度≤312μg/mL时，细胞活力超过97%。食用霍香精油对H1299肺癌细胞的细胞毒性最高（IC = 11μg/mL），表明其具有显著的抗癌功效。α - 葡萄糖苷酶抑制作用证明了其抗糖尿病作用，其中食用霍香精油的活性最强（IC = 248.1μg/mL）。二苯基苦味酰基自由基（DPPH）实验表明，食用霍香表现出最高的抗氧化活性（IC = 5923μg/mL）。研究结果突出了这些精油的药用潜力，包括食用霍香在抗癌、抗氧化和抗糖尿病方面的应用，以及柠檬桉和加拿大薄荷在抗病毒方面的应用。当前的研究工作符合可持续发展目标（SDG）的四个目标，具体如下：SDG 3：良好健康与福祉；SDG 12：负责任的消费和生产；SDG 9：产业、创新和基础设施；SDG 15：陆地生物。
