Department of Pharmacy and Ecological Chemistry, University of Opole, 45-052 Opole, Poland.
Department of Drug Technology and Biopharmacy, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine.
Molecules. 2023 Nov 6;28(21):7444. doi: 10.3390/molecules28217444.
This review aims to analyze L. as a potential raw material for the development of new health-promoting products (nutraceuticals, cosmetics, and pharmaceutical products). A lot of scientific publications were retrieved from the Scopus, PubMed, and Google Scholar databases which enable the study and generalization of the extraction procedures, key biologically active compounds of essential oil and extracts, biological properties, and therapeutic potential of , along with perspectives on the development of its dosage forms, including combinations of synthetic active substances and herbal preparations of . The results of this review indicate that is a source rich in phytoconstituents of different chemical nature and can be regarded as a source of active substances to enhance health and to develop medicinal products for complementary therapy of various conditions, especially those related with oxidant stress, inflammation, and moderate infections. Essential oil has a broad spectrum of activities. Depending on the test and concentration, this essential oil has both anti- and prooxidant properties. Gram-positive bacteria are more sensitive to the essential oil of than Gram-negative ones. This review also considered some facets of the standardization of essential oil and extracts of . Among the identified phenolics of extracts were caffeic acid, rosmarinic acid, eriocitrin, luteolin derivates (luteolin-7--rutinoside, luteolin-7--glucoronide), and hesperidin. The concentration of these phenolics depends on the solvent used. This review also considered the relationships between the chemical component and biological activity. The results showed that the essential oil and extracts reduced inflammation in vitro by inhibiting the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and in vivo by reducing the paw edema induced using carrageenan injection in rats. Therefore, herbal preparations of are promising medicinal and cosmetic preparations for their usage in skincare and oral cavity care products with antimicrobial, anti-inflammatory, and wound-healing properties. This plant can also be regarded as a platform for the development of antibacterial preparations and combined anti-inflammatory and cardioprotective medicinal products (synthetic active substances plus herbal preparations). This review could be considered for the justification of the composition of some medicinal products during their pharmaceutical development for writing a registration dossier in the format of Common Technical Document.
本文旨在分析迷迭香作为一种潜在的新的健康促进产品（营养保健品、化妆品和药物产品）的原材料。从 Scopus、PubMed 和 Google Scholar 数据库中检索到了大量科学出版物，这些出版物使我们能够对提取程序、精油和提取物的关键生物活性化合物、生物学特性和治疗潜力进行研究和概括，同时还展望了其剂型开发的前景，包括合成活性物质与 的草药制剂的组合。本文的综述结果表明，迷迭香是一种富含不同化学性质的植物成分的来源，可以被视为增强健康和开发用于补充治疗各种疾病的药物的活性物质的来源，特别是那些与氧化应激、炎症和中度感染相关的疾病。迷迭香精油具有广泛的活性。根据测试和浓度的不同，这种精油具有抗氧化和促氧化特性。革兰氏阳性菌比革兰氏阴性菌对迷迭香精油更为敏感。本文还考虑了迷迭香精油和提取物标准化的一些方面。提取物中的酚类化合物包括咖啡酸、迷迭香酸、桔皮苷、木犀草素衍生物（木犀草素-7-O-芸香糖苷、木犀草素-7-O-葡萄糖醛酸苷）和橙皮苷。这些酚类化合物的浓度取决于所用溶剂。本文还考虑了化学成分与生物活性之间的关系。结果表明，精油和提取物通过抑制促炎细胞因子（如肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6））的产生，在体外和体内减轻了角叉菜胶诱导的大鼠爪肿胀，从而减轻了炎症。因此，迷迭香草药制剂有望成为具有抗菌、抗炎和伤口愈合特性的药用和化妆品制剂，用于皮肤护理和口腔护理产品。这种植物还可以被视为开发抗菌制剂和联合抗炎和心脏保护药物（合成活性物质加草药制剂）的平台。本文的综述结果可用于在药物开发过程中为某些药物的组成提供合理性，以在通用技术文件格式下编写注册文件。
