绘制和模拟病毒B细胞表位的策略。
Strategies for mapping and imitating viral B-cell epitopes.
作者信息
Cason J
机构信息
Richard Dimbleby Laboratory for Cancer Virology, Rayne Institute, St Thomas' Hospital, London, UK.
出版信息
J Virol Methods. 1994 Sep;49(2):209-19. doi: 10.1016/0166-0934(94)90045-0.
Abstract
Identification of viral B-cell epitopes is of importance in the selection of peptides for inclusion into subunit vaccines, the development of virus-specific serological tests and understanding the interaction of antibodies with viruses at a molecular level. B-cell epitopes can often be determined unequivocally by X-ray analyses of antibody-antigen complexes. This technique is, however, time-consuming and alternative strategies have now been developed for identifying epitopes. This article provides an overview of approaches which are currently available for mapping and imitating B-cell epitopes.
摘要
鉴定病毒B细胞表位对于选择纳入亚单位疫苗的肽段、开发病毒特异性血清学检测以及在分子水平上理解抗体与病毒的相互作用至关重要。B细胞表位通常可通过抗体 - 抗原复合物的X射线分析明确确定。然而，该技术耗时，目前已开发出其他策略来鉴定表位。本文概述了目前可用于绘制和模拟B细胞表位的方法。
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