Apostolides Z, Weisburger J H
Department of Biochemistry, University of Pretoria, South Africa.
Mutat Res. 1995 Feb;326(2):219-25. doi: 10.1016/0027-5107(94)00175-5.
Standard black and green tea extracts have been known to inhibit mutagenicity caused by PhIP, in the Salmonella typhimurium TA98 assay containing S9 fraction from the liver of rats induced with alpha-naphthoflavone and phenobarbital. Breeding and selection programs for high yielding tea clones have successfully increased yields in many tea producing areas. Six clonal teas and three seedling teas were obtained from a tea producing area in Southern Africa. Standard black and green teas were used as controls. Dose-dependent inhibition of the bacterial mutagenicity elicited by two concentrations of PhIP was found in the extracts of all the teas tested. This indicates that the clonal teas have not lost their anti-mutagenic properties. Small differences were found amongst the clonal teas in their ability to inhibit mutagenicity. This indicates that it may be possible to enhance this trait in future breeding and selection programs.
在含有经α-萘黄酮和苯巴比妥诱导的大鼠肝脏S9组分的鼠伤寒沙门氏菌TA98试验中，标准红茶和绿茶提取物已知可抑制由PhIP引起的致突变性。高产茶树无性系的选育计划已在许多茶叶产区成功提高了产量。从南部非洲的一个茶叶产区获得了六个无性系茶和三个实生苗茶。标准红茶和绿茶用作对照。在所测试的所有茶叶提取物中，发现两种浓度的PhIP引起的细菌致突变性受到剂量依赖性抑制。这表明无性系茶没有丧失其抗诱变特性。在无性系茶抑制致突变性的能力方面发现了细微差异。这表明在未来的选育计划中有可能增强这一特性。
