Haefliger E, Parel J M
Vista Eye Institute, Binningen, Switzerland.
J Refract Corneal Surg. 1994 Sep-Oct;10(5):550-5.
After accommodative changes of endocapsular silicone lenses in presenile nonhuman primates had been confirmed by several authors, this pilot study was designed to evaluate the ability of an artificial lens to restore accommodation in the senile eye of a rhesus monkey that had previously lost most of its accommodative capability.
An injectable silicone lens was implanted in one eye of six rhesus monkeys who were older than 17 years. Accommodation was documented as the amount of decrease of anterior chamber depth after pilocarpine stimulation.
Four months after surgery, the decrease of anterior chamber depth was higher in the operated eye with the silicone intraocular lens in the two monkeys who had marked presbyopic changes in the natural lens. One monkey was kept for more than 4 years, retaining a decrease of at least 0.5 mm with the silicone lens, whereas the natural lens failed to show any accommodative change.
These findings support recent reports that presbyopia is primarily a consequence of lenticular aging rather than ciliary muscle factors. A pliable injected lens may therefore have the potential to restore accommodation in the senile primate eye.
在几位作者证实了幼年非人类灵长类动物眼内硅胶晶状体的调节变化后，本初步研究旨在评估一种人工晶状体恢复先前已丧失大部分调节能力的恒河猴老年眼调节功能的能力。
将可注射硅胶晶状体植入6只年龄超过17岁的恒河猴的一只眼中。调节功能通过毛果芸香碱刺激后前房深度的减少量来记录。
手术后4个月，在天然晶状体有明显老花眼变化的两只猴子中，植入硅胶人工晶状体的术眼的前房深度减少量更大。一只猴子饲养了4年多，硅胶晶状体使其前房深度至少减少0.5mm，而天然晶状体未显示任何调节变化。
这些发现支持了最近的报道，即老花眼主要是晶状体老化的结果，而非睫状肌因素。因此，一种可弯曲的注射式晶状体可能有恢复老年灵长类动物眼调节功能的潜力。
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