Shattil S J, Ginsberg M H, Brugge J S
Division of Hematology-Oncology, University of Pennsylvania Medical Center, Philidelphia 19104.
Curr Opin Cell Biol. 1994 Oct;6(5):695-704. doi: 10.1016/0955-0674(94)90096-5.
The anucleate platelet must perform its hemostatic functions in the absence of transcriptional regulation. Central among these functions is cell adhesion, which is mediated by multiple specialized plasma membrane receptors. The adhesive function of one of the key receptors, integrin alpha IIb beta 3, is regulated by intracellular signals triggered by platelet agonists and antagonists. Recent evidence indicates that adhesion receptors can transduce extracellular signals into the platelet to activate intracellular signaling pathways that affect hemostasis.
无核血小板必须在缺乏转录调控的情况下执行其止血功能。这些功能中核心的是细胞黏附，它由多种特殊的质膜受体介导。关键受体之一整合素αIIbβ3的黏附功能受血小板激动剂和拮抗剂触发的细胞内信号调节。最近的证据表明，黏附受体可将细胞外信号转导至血小板内，以激活影响止血的细胞内信号通路。
