Sherman L, Sleeman J, Herrlich P, Ponta H
Institut für Genetik, Kernforschungszentrum Karlsruhe, Germany.
Curr Opin Cell Biol. 1994 Oct;6(5):726-33. doi: 10.1016/0955-0674(94)90100-7.
Hyaluronate (HA) is an abundant component of extracellular matrix that is believed to be crucial in many cellular processes, including tissue remodeling, the creation of cell-free spaces, inflammation and tumorigenesis. Although several well characterized proteins within the extracellular matrix associate with HA, it is now clear that cells can also bind and respond to HA directly, via cell-surface HA-binding proteins. The cDNAs coding for two families of such proteins, CD44 and RHAMM, have been cloned and characterized. These proteins have been implicated in a number of physiological processes, including cell migration, lymphocyte activation and tumor progression. Although many of these processes depend on an association with HA, some are apparently HA-independent, suggesting that other ligands for these receptors may be involved.
透明质酸（HA）是细胞外基质的一种丰富成分，据信在许多细胞过程中起着关键作用，包括组织重塑、无细胞空间的形成、炎症和肿瘤发生。尽管细胞外基质中有几种特征明确的蛋白质与HA相关联，但现在很清楚，细胞也可以通过细胞表面HA结合蛋白直接结合并对HA作出反应。编码此类蛋白质两个家族（CD44和RHAMM）的cDNA已被克隆和鉴定。这些蛋白质参与了许多生理过程，包括细胞迁移、淋巴细胞活化和肿瘤进展。尽管这些过程中的许多都依赖于与HA的关联，但有些显然不依赖于HA，这表明这些受体的其他配体可能也参与其中。
