重组人粒细胞集落刺激因子（rh G-CSF）治疗药物性粒细胞缺乏症
Treatment of drug-induced agranulocytosis with recombinant granulocyte colony-stimulating factor (rh G-CSF).
作者信息
Willfort A, Lorber C, Kapiotis S, Sertl S, Hainz R, Kirchweger P, Jäger U, Kyrle P A, Lechner K, Geissler K
机构信息
First Department of Internal Medicine, Division of Hematology and Blood Coagulation, Vienna, Austria.
出版信息
Ann Hematol. 1993 May;66(5):241-4. doi: 10.1007/BF01738472.
Five patients with drug-induced agranulocytosis received 300 micrograms recombinant human granulocyte colony-stimulating factor (rh G-CSF) subcutaneously twice daily for 2-5 days. G-CSF therapy resulted in a steep increase of the neutrophil count, which was faster than that in patients with spontaneous recovery reported in the literature. In all four patients with infectious complications fever rapidly declined with the increase of granulocytes. G-CSF may be useful in the management of drug-induced agranulocytosis.
5例药物性粒细胞缺乏症患者接受了重组人粒细胞集落刺激因子（rh G-CSF）皮下注射，剂量为300微克，每日2次，共治疗2 - 5天。G-CSF治疗使中性粒细胞计数急剧上升，其上升速度比文献报道的自然恢复患者更快。在所有4例有感染并发症的患者中，随着粒细胞数量的增加，发热迅速消退。G-CSF可能有助于药物性粒细胞缺乏症的治疗。
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